Biodegradable　stents　made　of　poly-L-lactic　acid　(　PLLA)　have　a　promising　prospect　thanks　to　high　biocompatibility　and　a　favorable　biodegradation　period.　However,　due　to　the　low　stiffness　of　PLLA,　polymeric　stents　have　a　lower　radial　stiffness　and　larger　foreshortening.　Furthermore,　a　stent　is　a　tiny　meshed　tube,　hence,　it　is　difficult　to　make　a　polymeric　stent.　In　the　present　study,　a　finite　element　analysis-based　optimization　method　combined　with　Kriging　surrogate　modeling　is　firstly　proposed　to　optimize　the　stent　structure　and　stent　microinjection　molding　process,　so　as　to　improve　the　stent　mechanical　properties　and　microinjection　molding　quality,　respectively.　The　Kriging　surrogate　models　are　constructed　to　formulate　the　approximate　mathematical　relationships　between　the　design　variables　and　design　objectives.　Expected　improvement　is　employed　to　balance　local　and　global　search　to　find　the　global　optimal　design.　As　an　example,　the　polymeric　ART18Z　stent　was　investigated.　The　mechanical　properties　of　stent　expansion　in　a　stenotic　artery　and　the　molding　quality　were　improved　after　optimization.　Numerical　results　demonstrate　the　proposed　optimization　method　can　be　used　for　the　computationally　measurable　optimality　of　stent　structure　design　and　stent　microinjection　molding　process.