Pervaporation　offers　advantages　over　traditional　separation　processes,　but　there　is　still　lack　of　scale-up　methods　and　manufacturing　systems　to　easily　and　controllably　obtain　the　defect-free　membranes.　In　this　work,　poly(dimethylsiloxane)/polysulfone　composite　membranes　were　scaled　up　using　a　roll-coating　method.　The　thickness　of　the　poly(dimethylsiloxane)　separation　layer　was　successfully　controlled　on　polysulfone　substrate　by　roll-coating　different　layers.　The　membranes　are　used　for　separating　ethanol/water　mixtures.　The　pervaporation　experiments　were　performed　(i)　in　the　laboratory　using　a　radial　cell　with　a　membrane　area　of　0.0028　m(2);　(ii)　in　a　large　cell　using　a　plate-and-frame　module　with　membrane　area　of　036　m(2);　and　(iii)　in　a　pilot　plant　located　at　an　industrial　site,　with　a　plate-and-frame　module　and　total　membrane　area　of　2.16　m(2).　On-site　operations　showed　that　the　flux　of　1000-1200　g　m(-2)　h(-1)　with　60-65　wt%　ethanol　in　permeate　was　achieved　by　the　pilot-scale　pervaporation　facility,　which　demonstrated　technical　feasibility　for　industrial　application.　(C)　2015　Elsevier　B.V.　All　rights　reserved.