The　vibration　active　control　of　the　composite　panels　with　the　uncertain　parameters　in　the　hypersonic　flow　is　studied　using　the　non-probabilistic　reliability　theory.　Using　the　piezoelectric　patches　as　active　control　actuators,　dynamic　equations　of　panel　are　established　by　finite　element　method　and　Hamilton＇s　principle.　And　the　control　model　of　panel　with　uncertain　parameters　is　obtained.　According　to　the　non-probabilistic　reliability　index,　and　besides　being　based　on　HN　robust　control　theory　and　non-probabilistic　reliability　theory,　the　non-probabilistic　reliability　performance　function　is　given.　Moreover,　the　relationships　between　the　robust　controller　and　HN　performance　index　and　reliability　are　established.　Numerical　results　show　that　the　control　method　under　the　influence　of　reliability,　HN　performance　index,　and　approaching　velocity　is　effective　to　the　vibration　suppression　of　panel　in　the　whole　interval　of　uncertain　parameters.