Newly　designed　3D　highly　ordered　macro/mesoporous　multifunctional　La1-xCexCoO3　nanohybrid　frameworks　with　a　2D　hexagonal　mesostructure　were　fabricated　via　facile　meso-molding　in　a　three-dimensionally　macroporous　perovskite　(MTMP)　route.　The　nanohybrid　framework　exhibited　excellent　catalytic　activity　for　methane　combustion,　which　derived　from　the　MTMP　providing　a　larger　surface　area　and　pore　volume,　uniform　pore　sizes,　higher　accessible　surface　oxygen　concentration,　better　low-temperature　reducibility,　and　a　unique　nanovoid　3D　structure.