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Author:

Berg, Philipp (Berg, Philipp.) | Roloff, Christoph (Roloff, Christoph.) | Beuing, Oliver (Beuing, Oliver.) | Voss, Samuel (Voss, Samuel.) | Sugiyama, Shin-Ichiro (Sugiyama, Shin-Ichiro.) | Aristokleous, Nicolas (Aristokleous, Nicolas.) | Anayiotos, Andreas S. (Anayiotos, Andreas S..) | Ashton, Neil (Ashton, Neil.) | Revell, Alistair (Revell, Alistair.) | Bressloff, Neil W. (Bressloff, Neil W..) | Brown, Alistair G. (Brown, Alistair G..) | Chung, Bong Jae (Chung, Bong Jae.) | Cebral, Juan R. (Cebral, Juan R..) | Copelli, Gabriele (Copelli, Gabriele.) | Fu, Wenyu (Fu, Wenyu.) | Qiao, Aike (Qiao, Aike.) (Scholars:乔爱科) | Geers, Arjan J. (Geers, Arjan J..) | Hodis, Simona (Hodis, Simona.) | Dragomir-Daescu, Dan (Dragomir-Daescu, Dan.) | Nordahl, Emily (Nordahl, Emily.) | Suzen, Yildirim Bora (Suzen, Yildirim Bora.) | Khan, Muhammad Owais (Khan, Muhammad Owais.) | Valen-Sendstad, Kristian (Valen-Sendstad, Kristian.) | Kono, Kenichi (Kono, Kenichi.) | Menon, Prahlad G. (Menon, Prahlad G..) | Albal, Priti G. (Albal, Priti G..) | Mierka, Otto (Mierka, Otto.) | Muenster, Raphael (Muenster, Raphael.) | Morales, Hernan G. (Morales, Hernan G..) | Bonnefous, Odile (Bonnefous, Odile.) | Osman, Jan (Osman, Jan.) | Goubergrits, Leonid (Goubergrits, Leonid.) | Pallares, Jordi (Pallares, Jordi.) | Cito, Salvatore (Cito, Salvatore.) | Passalacqua, Alberto (Passalacqua, Alberto.) | Piskin, Senol (Piskin, Senol.) | Pekkan, Kerem (Pekkan, Kerem.) | Ramalho, Susana (Ramalho, Susana.) | Marques, Nelson (Marques, Nelson.) | Sanchi, Stephane (Sanchi, Stephane.) | Schumacher, Kristopher R. (Schumacher, Kristopher R..) | Sturgeon, Jess (Sturgeon, Jess.) | Svihlova, Helena (Svihlova, Helena.) | Hron, Jaroslav (Hron, Jaroslav.) | Usera, Gabriel (Usera, Gabriel.) | Mendina, Mariana (Mendina, Mariana.) | Xiang, Jianping (Xiang, Jianping.) | Meng, Hui (Meng, Hui.) | Steinman, David A. (Steinman, David A..) | Janiga, Gabor (Janiga, Gabor.)

Indexed by:

EI Scopus SCIE

Abstract:

With the increased availability of computational resources, the past decade has seen a rise in the use of computational fluid dynamics (CFD) for medical applications. There has been an increase in the application of CFD to attempt to predict the rupture of intracranial aneurysms, however, while many hemodynamic parameters can be obtained from these computations, to date, no consistent methodology for the prediction of the rupture has been identified. One particular challenge to CFD is that many factors contribute to its accuracy; the mesh resolution and spatial/temporal discretization can alone contribute to a variation in accuracy. This failure to identify the importance of these factors and identify a methodology for the prediction of ruptures has limited the acceptance of CFD among physicians for rupture prediction. The International CFD Rupture Challenge 2013 seeks to comment on the sensitivity of these various CFD assumptions to predict the rupture by undertaking a comparison of the rupture and blood-flow predictions from a wide range of independent participants utilizing a range of CFD approaches. Twenty-six groups from 15 countries took part in the challenge. Participants were provided with surface models of two intracranial aneurysms and asked to carry out the corresponding hemodynamics simulations, free to choose their own mesh, solver, and temporal discretization. They were requested to submit velocity and pressure predictions along the center-line and on specified planes. The first phase of the challenge, described in a separate paper, was aimed at predicting which of the two aneurysms had previously ruptured and where the rupture site was located. The second phase, described in this paper, aims to assess the variability of the solutions and the sensitivity to the modeling assumptions. Participants were free to choose boundary conditions in the first phase, whereas they were prescribed in the second phase but all other CFD modeling parameters were not prescribed. In order to compare the computational results of one representative group with experimental results, steady-flow measurements using particle image velocimetry (PIV) were carried out in a silicone model of one of the provided aneurysms. Approximately 80% of the participating groups generated similar results. Both velocity and pressure computations were in good agreement with each other for cycle-averaged and peak-systolic predictions. Most apparent "outliers" (results that stand out of the collective) were observed to have underestimated velocity levels compared to the majority of solutions, but nevertheless identified comparable flow structures. In only two cases, the results deviate by over 35% from the mean solution of all the participants. Results of steady CFD simulations of the representative group and PIV experiments were in good agreement. The study demonstrated that while a range of numerical schemes, mesh resolution, and solvers was used, similar flow predictions were observed in the majority of cases. To further validate the computational results, it is suggested that time-dependent measurements should be conducted in the future. However, it is recognized that this study does not include the biological aspects of the aneurysm, which needs to be considered to be able to more precisely identify the specific rupture risk of an intracranial aneurysm.

Keyword:

intracranial aneurysm challenge computational fluid dynamics variability

Author Community:

  • [ 1 ] [Berg, Philipp]Univ Magdeburg, D-39106 Magdeburg, Germany
  • [ 2 ] [Roloff, Christoph]Univ Magdeburg, D-39106 Magdeburg, Germany
  • [ 3 ] [Voss, Samuel]Univ Magdeburg, D-39106 Magdeburg, Germany
  • [ 4 ] [Janiga, Gabor]Univ Magdeburg, D-39106 Magdeburg, Germany
  • [ 5 ] [Beuing, Oliver]Univ Hosp Magdeburg, D-39120 Magdeburg, Germany
  • [ 6 ] [Sugiyama, Shin-Ichiro]Tohoku Univ, Grad Sch Med, Sendai, Miyagi 9808574, Japan
  • [ 7 ] [Aristokleous, Nicolas]Cyprus Univ Technol, CY-3036 Lemesos, Cyprus
  • [ 8 ] [Anayiotos, Andreas S.]Cyprus Univ Technol, CY-3036 Lemesos, Cyprus
  • [ 9 ] [Ashton, Neil]Univ Manchester, Manchester M60 1QD, Lancs, England
  • [ 10 ] [Revell, Alistair]Univ Manchester, Manchester M60 1QD, Lancs, England
  • [ 11 ] [Bressloff, Neil W.]Univ Southampton, Southampton SO17 1BJ, Hants, England
  • [ 12 ] [Brown, Alistair G.]CD Adapco, London W6 7NL, England
  • [ 13 ] [Chung, Bong Jae]George Mason Univ, Fairfax, VA 22030 USA
  • [ 14 ] [Cebral, Juan R.]George Mason Univ, Fairfax, VA 22030 USA
  • [ 15 ] [Copelli, Gabriele]Univ Parma, I-43125 Parma, Italy
  • [ 16 ] [Fu, Wenyu]Beijing Univ Technol, Beijing 100124, Peoples R China
  • [ 17 ] [Qiao, Aike]Beijing Univ Technol, Beijing 100124, Peoples R China
  • [ 18 ] [Geers, Arjan J.]Univ Pompeu Fabra, Barcelona 08002, Spain
  • [ 19 ] [Hodis, Simona]Texas A&M Univ, Kingsville, TX 78363 USA
  • [ 20 ] [Dragomir-Daescu, Dan]Texas A&M Univ, Kingsville, TX 78363 USA
  • [ 21 ] [Hodis, Simona]Mayo Clin, Rochester, MN 55905 USA
  • [ 22 ] [Dragomir-Daescu, Dan]Mayo Clin, Rochester, MN 55905 USA
  • [ 23 ] [Nordahl, Emily]N Dakota State Univ, Fargo, ND 58102 USA
  • [ 24 ] [Suzen, Yildirim Bora]N Dakota State Univ, Fargo, ND 58102 USA
  • [ 25 ] [Khan, Muhammad Owais]Univ Toronto, Toronto, ON M5S 3G8, Canada
  • [ 26 ] [Valen-Sendstad, Kristian]Univ Toronto, Toronto, ON M5S 3G8, Canada
  • [ 27 ] [Steinman, David A.]Univ Toronto, Toronto, ON M5S 3G8, Canada
  • [ 28 ] [Kono, Kenichi]Wakayama Rosai Hosp, Wakayama 6408505, Japan
  • [ 29 ] [Menon, Prahlad G.]Sun Yat Sen Univ Carnegie Mellon Univ Joint Inst, Pittsburgh, PA 15219 USA
  • [ 30 ] [Albal, Priti G.]Sun Yat Sen Univ Carnegie Mellon Univ Joint Inst, Pittsburgh, PA 15219 USA
  • [ 31 ] [Mierka, Otto]Univ Dortmund, D-44227 Dortmund, Germany
  • [ 32 ] [Muenster, Raphael]Univ Dortmund, D-44227 Dortmund, Germany
  • [ 33 ] [Morales, Hernan G.]Medisys Philips Res, F-92156 Paris, France
  • [ 34 ] [Bonnefous, Odile]Medisys Philips Res, F-92156 Paris, France
  • [ 35 ] [Osman, Jan]Charite, D-13353 Berlin, Germany
  • [ 36 ] [Goubergrits, Leonid]Charite, D-13353 Berlin, Germany
  • [ 37 ] [Pallares, Jordi]Univ Rovira & Virgili, E-43007 Tarragona, Spain
  • [ 38 ] [Cito, Salvatore]Univ Rovira & Virgili, E-43007 Tarragona, Spain
  • [ 39 ] [Passalacqua, Alberto]Iowa State Univ, Ames, IA 50011 USA
  • [ 40 ] [Piskin, Senol]Koc Univ, TR-34450 Istanbul, Turkey
  • [ 41 ] [Pekkan, Kerem]Koc Univ, TR-34450 Istanbul, Turkey
  • [ 42 ] [Ramalho, Susana]BlueCAPE Lda CAE Solut, P-2665305 Milharado, Portugal
  • [ 43 ] [Marques, Nelson]BlueCAPE Lda CAE Solut, P-2665305 Milharado, Portugal
  • [ 44 ] [Schumacher, Kristopher R.]MRIGlobal, Kansas City, MO 64110 USA
  • [ 45 ] [Sturgeon, Jess]MRIGlobal, Kansas City, MO 64110 USA
  • [ 46 ] [Svihlova, Helena]Charles Univ Prague, Prague 18675, Czech Republic
  • [ 47 ] [Hron, Jaroslav]Charles Univ Prague, Prague 18675, Czech Republic
  • [ 48 ] [Usera, Gabriel]Gabriel Usera, Montevideo 11300, Uruguay
  • [ 49 ] [Mendina, Mariana]Gabriel Usera, Montevideo 11300, Uruguay
  • [ 50 ] [Xiang, Jianping]SUNY Buffalo, Buffalo, NY 14203 USA
  • [ 51 ] [Meng, Hui]SUNY Buffalo, Buffalo, NY 14203 USA

Reprint Author's Address:

  • [Berg, Philipp]Univ Magdeburg, D-39106 Magdeburg, Germany

Email:

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Source :

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

ISSN: 0148-0731

Year: 2015

Issue: 12

Volume: 137

1 . 7 0 0

JCR@2022

ESI Discipline: ENGINEERING;

ESI HC Threshold:174

JCR Journal Grade:3

CAS Journal Grade:3

Cited Count:

WoS CC Cited Count: 72

SCOPUS Cited Count: 80

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 8

Online/Total:537/10713078
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