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Author:

Ren, H. X. (Ren, H. X..) | Liu, Sh. Q. (Liu, Sh. Q..) | Zhang, X. C. (Zhang, X. C..) | Zeng, Y. J. (Zeng, Y. J..)

Indexed by:

Scopus SCIE

Abstract:

Spike timing-dependent plasticity (STDP) plays an important role in sculpting information-storing circuits in the hippocampus, since motor learning and memory are thought to be closely linked with this classical plasticity. To further understand the information delivery in a hippocampus circuit, we build a computational model to study the potential role of linear changes in the synaptic weight and synaptic number. Several key results have been obtained: (i) Changes in the synaptic weight and numbers lead to different long-term modifications; (ii) the first paired spiking from two neurons significantly influences the adjusted subsequent paired spiking; the pre-post spiking pair strengthens the following paired spiking; however, the post-pre spiking pair depresses the subsequent spiking; (iii) when the synaptic weight and synaptic numbers are changed, the interval of the first spiking pair may undergo reduction, and (iv) when we stimulate a stellate neuron weakly or decrease the capacitance of the CA1 pyramidal neuron, LTP is more easily produced than LTD; on the contrary, LTD is more easily produced in an opposite situation; increase in the synaptic numbers can promote activation of the CA1 pyramidal neuron.

Keyword:

hippocampus neuronal circuits synaptic weight and number computational model spike timing-dependent synaptic plasticity (STDP)

Author Community:

  • [ 1 ] [Ren, H. X.]S China Univ Technol, Dept Math, Guangzhou, Guangdong, Peoples R China
  • [ 2 ] [Liu, Sh. Q.]S China Univ Technol, Dept Math, Guangzhou, Guangdong, Peoples R China
  • [ 3 ] [Zhang, X. C.]S China Univ Technol, Dept Math, Guangzhou, Guangdong, Peoples R China
  • [ 4 ] [Zeng, Y. J.]Beijing Univ Technol, Ctr Biomed Engn, Beijing, Peoples R China

Reprint Author's Address:

  • [Liu, Sh. Q.]S China Univ Technol, Dept Math, Guangzhou, Guangdong, Peoples R China

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Source :

NEUROPHYSIOLOGY

ISSN: 0090-2977

Year: 2015

Issue: 4

Volume: 47

Page: 264-270

0 . 5 0 0

JCR@2022

ESI Discipline: NEUROSCIENCE & BEHAVIOR;

ESI HC Threshold:252

JCR Journal Grade:4

CAS Journal Grade:4

Cited Count:

WoS CC Cited Count: 0

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 4

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