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Abstract:
Spike timing-dependent plasticity (STDP) plays an important role in sculpting information-storing circuits in the hippocampus, since motor learning and memory are thought to be closely linked with this classical plasticity. To further understand the information delivery in a hippocampus circuit, we build a computational model to study the potential role of linear changes in the synaptic weight and synaptic number. Several key results have been obtained: (i) Changes in the synaptic weight and numbers lead to different long-term modifications; (ii) the first paired spiking from two neurons significantly influences the adjusted subsequent paired spiking; the pre-post spiking pair strengthens the following paired spiking; however, the post-pre spiking pair depresses the subsequent spiking; (iii) when the synaptic weight and synaptic numbers are changed, the interval of the first spiking pair may undergo reduction, and (iv) when we stimulate a stellate neuron weakly or decrease the capacitance of the CA1 pyramidal neuron, LTP is more easily produced than LTD; on the contrary, LTD is more easily produced in an opposite situation; increase in the synaptic numbers can promote activation of the CA1 pyramidal neuron.
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NEUROPHYSIOLOGY
ISSN: 0090-2977
Year: 2015
Issue: 4
Volume: 47
Page: 264-270
0 . 5 0 0
JCR@2022
ESI Discipline: NEUROSCIENCE & BEHAVIOR;
ESI HC Threshold:252
JCR Journal Grade:4
CAS Journal Grade:4
Cited Count:
WoS CC Cited Count: 0
SCOPUS Cited Count:
ESI Highly Cited Papers on the List: 0 Unfold All
WanFang Cited Count:
Chinese Cited Count:
30 Days PV: 4
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