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Author:

Xiang, Jie (Xiang, Jie.) | Guo, Hao (Guo, Hao.) | Cao, Rui (Cao, Rui.) | Liang, Hong (Liang, Hong.) | Chen, Junjie (Chen, Junjie.)

Indexed by:

Scopus SCIE PubMed CSCD

Abstract:

Brain structure and cognitive function change in the temporal lobe, hippocampus, and prefrontal cortex of patients with mild cognitive impairment and Alzheimer's disease, and brain network-connection strength, network efficiency, and nodal attributes are abnormal. However, existing research has only analyzed the differences between these patients and normal controls. In this study, we constructed brain networks using resting-state functional MRI data that was extracted from four populations (normal controls, patients with early mild cognitive impairment, patients with late mild cognitive impairment, and patients with Alzheimer's disease) using the Alzheimer's Disease Neuroimaging Initiative data set. The aim was to analyze the characteristics of resting-state functional neural networks, and to observe mild cognitive impairment at different stages before the transformation to Alzheimer's disease. Results showed that as cognitive deficits increased across the four groups, the shortest path in the resting-state functional network gradually increased, while clustering coefficients gradually decreased. This evidence indicates that dementia is associated with a decline of brain network efficiency. In addition, the changes in functional networks revealed the progressive deterioration of network function across brain regions from healthy elderly adults to those with mild cognitive impairment and Alzheimer's disease. The alterations of node attributes in brain regions may reflect the cognitive functions in brain regions, and we speculate that early impairments in memory, hearing, and language function can eventually lead to diffuse brain injury and other cognitive impairments.

Keyword:

neural regeneration Alzheimer's disease neurodegeneration late mild cognitive impairment grants-supported paper neuroregeneration aging graph theory resting state diffuse brain disease functional MRI human connectonne early mild cognitive impairment small world property

Author Community:

  • [ 1 ] [Xiang, Jie]Taiyuan Univ Technol, Coll Comp Sci & Technol, Taiyuan 030024, Shanxi Province, Peoples R China
  • [ 2 ] [Guo, Hao]Taiyuan Univ Technol, Coll Comp Sci & Technol, Taiyuan 030024, Shanxi Province, Peoples R China
  • [ 3 ] [Cao, Rui]Taiyuan Univ Technol, Coll Comp Sci & Technol, Taiyuan 030024, Shanxi Province, Peoples R China
  • [ 4 ] [Liang, Hong]Taiyuan Univ Technol, Coll Comp Sci & Technol, Taiyuan 030024, Shanxi Province, Peoples R China
  • [ 5 ] [Chen, Junjie]Taiyuan Univ Technol, Coll Comp Sci & Technol, Taiyuan 030024, Shanxi Province, Peoples R China
  • [ 6 ] [Xiang, Jie]Beijing Univ Technol, Int WIC Inst, Beijing 100022, Peoples R China

Reprint Author's Address:

  • [Chen, Junjie]Taiyuan Univ Technol, Coll Comp Sci & Technol, Taiyuan 030024, Shanxi Province, Peoples R China

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Source :

NEURAL REGENERATION RESEARCH

ISSN: 1673-5374

Year: 2013

Issue: 30

Volume: 8

Page: 2789-2799

6 . 1 0 0

JCR@2022

ESI Discipline: NEUROSCIENCE & BEHAVIOR;

JCR Journal Grade:4

CAS Journal Grade:4

Cited Count:

WoS CC Cited Count: 41

SCOPUS Cited Count: 46

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 4

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