• Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
搜索

Author:

Shen, Feng (Shen, Feng.) | Li, Zonghe (Li, Zonghe.) | Xue, Sen (Xue, Sen.) | Li, Mengqi (Li, Mengqi.) | Liu, Zhaomiao (Liu, Zhaomiao.) (Scholars:刘赵淼)

Indexed by:

EI Scopus SCIE

Abstract:

Particle/cell separation from a mixture using a hydrodynamic vortex has been attracting much interest for the isolation of circulating tumor cells in basic biological studies and clinical applications. However, some issues regarding the particle recirculating orbits within the vortex in microcavities remain unclear. In this work, using micro-particle image velocimetry and a high-speed microscopy system, we quantitatively investigate the effects of inlet Reynolds numbers (Re) on the microcavity flow characteristics and particle recirculating behavior. The results show that due to the evolution of microcavity flow patterns (Re = 15-313), the particle orbit topology expands gradually, developing from a single small orbit (Re = 39-79) to a single semicircular orbit (98-117), then to alternating double orbits (Re = 136-215), and at last to a single large orbit (Re = 254-352). The alternating double orbits are observed for the first time. The particle orbit periods and topologies (lengths and area) have also been characterized. Moreover, the variations of the recirculating particle velocity are also quantitatively measured. The results deepen the fundamental understanding of particle recirculating behavior and could provide useful guidance for vortex-based microfluidics.

Keyword:

microfluidics vortex microcavity particle orbit cell separation particle

Author Community:

  • [ 1 ] [Shen, Feng]Beijing Univ Technol, Fac Mat & Mfg, Beijing 100124, Peoples R China
  • [ 2 ] [Li, Zonghe]Beijing Univ Technol, Fac Mat & Mfg, Beijing 100124, Peoples R China
  • [ 3 ] [Xue, Sen]Beijing Univ Technol, Fac Mat & Mfg, Beijing 100124, Peoples R China
  • [ 4 ] [Li, Mengqi]Beijing Univ Technol, Fac Mat & Mfg, Beijing 100124, Peoples R China
  • [ 5 ] [Liu, Zhaomiao]Beijing Univ Technol, Fac Mat & Mfg, Beijing 100124, Peoples R China
  • [ 6 ] [Shen, Feng]Beijing Univ Technol, Inst Adv Mech Engn, Beijing 100124, Peoples R China
  • [ 7 ] [Li, Zonghe]Beijing Univ Technol, Inst Adv Mech Engn, Beijing 100124, Peoples R China
  • [ 8 ] [Xue, Sen]Beijing Univ Technol, Inst Adv Mech Engn, Beijing 100124, Peoples R China
  • [ 9 ] [Li, Mengqi]Beijing Univ Technol, Inst Adv Mech Engn, Beijing 100124, Peoples R China
  • [ 10 ] [Liu, Zhaomiao]Beijing Univ Technol, Inst Adv Mech Engn, Beijing 100124, Peoples R China
  • [ 11 ] [Shen, Feng]Beijing Univ Technol, Beijing Key Lab Adv Mfg Technol, Beijing 100124, Peoples R China

Reprint Author's Address:

  • 刘赵淼

    [Liu, Zhaomiao]Beijing Univ Technol, Fac Mat & Mfg, Beijing 100124, Peoples R China;;[Liu, Zhaomiao]Beijing Univ Technol, Inst Adv Mech Engn, Beijing 100124, Peoples R China

Show more details

Related Keywords:

Source :

JOURNAL OF PHYSICS D-APPLIED PHYSICS

ISSN: 0022-3727

Year: 2021

Issue: 2

Volume: 54

3 . 4 0 0

JCR@2022

ESI Discipline: PHYSICS;

ESI HC Threshold:72

JCR Journal Grade:2

Cited Count:

WoS CC Cited Count: 12

SCOPUS Cited Count: 13

ESI Highly Cited Papers on the List: 1 Unfold All

  • 2021-7

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 11

Online/Total:319/10804206
Address:BJUT Library(100 Pingleyuan,Chaoyang District,Beijing 100124, China Post Code:100124) Contact Us:010-67392185
Copyright:BJUT Library Technical Support:Beijing Aegean Software Co., Ltd.