An　efficient　synthetic　method　of　substituted　meso-tetraphenylporphyrins　with　better　isolated　yields　was　proposed　by　using　propionic　acid,　valeric　acid　and　m-nitrotoluene　as　mixed-solvent　systems.　The　porphyrin　yields　in　mixed　solvent　systems　were　obviously　higher　than　those　in　the　single　propionic　acid　or　valeric　acid　as　solvents.　The　further　investigation　showed　that　the　acidity,　polarity,　viscosity　and　the　property　of　oxidant　played　an　important　role　to　the　synthesis　of　porphyrin.　Compared　with　other　oxidants,　m-nitrotoluene　as　an　excellent　oxidant　could　completely　transform　tetraphenylporphyrinogen　to　tetraphenylporphyrin.