The　intra-aorta　pump　proposed　here　is　a　novel　left　ventricular　assist　device　(LVAD).　The　mathematic　model　and　the　in　vitro　experiment　demonstrate　that　the　pump　can　satisfy　the　demand　of　human　blood　perfusion.　However,　the　implantation　of　LVAD　will　change　the　fluid　distribution　or　even　generate　a　far-reaching　influence　on　the　aorta.　At　present,　the　characteristics　of　endaortic　hemodynamics　under　the　support　of　intra-aorta　pump　are　still　unclear.　In　this　article,　a　computational　fluid　dynamics　study　based　on　a　finite-element　method　was　performed　for　the　aorta　under　the　support　of　intra-aorta　pump.　To　explore　the　hemodynamic　influence　of　intra-aorta　pump　on　aorta,　fully　coupled　fluid-solid　interaction　simulation　was　used　in　this　study.　From　the　flow　profiles,　we　observed　that　the　maximum　disturbed　flow　and　nonuniform　flow　existed　within　the　aortic　arch　and　the　branches　of　the　aortic　arch.　Flow　waveforms　at　the　inlets　of　aortas　were　derived　from　the　lumped　parameter　model　that　we　proposed　in　our　previous　study.　The　results　demonstrated　that　the　intra-aorta　pump　increased　the　blood　flow　in　the　aorta　to　normal　physiologic　conditions,　but　decreased　the　pulsatility　of　the　flow　and　pressure.　The　pulsatility　index　changed　from　2,540　to　1,370.　The　pressure　gradient　(PG)　for　heart　failure　conditions　was　18.88　mm　Hg/m　vs.　25.51　mm　Hg/m　for　normal　physiologic　conditions;　for　intra-aorta　pump　assist　conditions,　normal　PG　value　could　not　be　regained.　Furthermore,　our　experimental　results　showed　that　the　wall　shear　stress　(WSS)　of　aorta　under　heart　failure　and　normal　physiologic　conditions　were　1.5　and　6.3　dynes/cm(2),　respectively.　The　intra-aorta　pump　increased　the　WSS　value　from　1.5　to　4.1　dynes/cm(2).　ASAIO　Journal　2012;58:462-469.