Endovascular　aneurysm　repair　(EVAR)　is　considered　as　a　promising　alternative　technique　for　the　treatment　of　aortic　aneurysm.　However,　complications　often　occur　after　EVAR.　In　this　paper,　the　influence　of　the　physiological　factors　on　the　biomechanical　behaviors　of　stented　and　non-stented　thoracic　aortic　aneurysm　(TAA)　were　presented.　Representative　TAA　models　with　different　intraluminal　thrombus　(ILT)　volume　before　and　after　stent-graft　(SG)　implantation　were　built.　Fluid-structure　interaction　effect　was　taken　into　account.　The　relative　sliding　between　the　SG　wall　and　the　aortic　wall　was　allowed.　Results　showed　that　the　cardiac　cycle　and　ILT　volume　should　be　given　much　more　consideration　than　previously　thought　in　future　investigations　on　TAA　compliance.　The　time-averaged　longitudinal　displacement　of　SG　necks　were　not　uniformly　distributed　along　circumferential　direction　of　the　aortic　wall.　Drag　force　increased　with　the　increase　of　the　cardiac　cycle　and　decreased　with　the　decrease　of　ILT　volume.　Computational　results　of　TAA　wall　stress,　sac　and　lumen　pressure　indicated　that　patient　with　faster　heart　rate　might　be　at　great　risk　of　aneurysm　rupture.　The　stress　absorption　effect　of　the　SG　was　influenced　by　both　ILT　and　cardiac　cycle,　which　was　also　found　to　have　strong　impact　on　flow　pattern.　We　believe　that　this　study　will　bring　new　insights　into　further　researches　on　the　relevant　issues　and　provide　mechanics-based　implications　for　clinical　management　of　EVAR　for　TAA　patient.　(C)　2011　Elsevier　Ltd.　All　rights　reserved.