(E)-N-[3-(4-Cinnamoylpiperazin-1-yl)propyl]-3,4-dihydroxybenzamide　and　(E)-N-[3-(4-cinnamoylpiperazin-1-yl)propyl]-3,4,5-trihydroxybenzamide　were　designed　and　synthesized　as　potential　HIV-1　integrase　inhibitors　and　evaluated　their　inhibition　to　the　strand　transfer　process　of　HIV-1　integrase.　The　result　indicates　that　3,4,5-trihydroxylated　aromatic　derivatives　exhibit　good　inhibition　to　HIV-1　integrase,　however,　corresponding　3,4-dihydroxylated　aromatic　derivatives　appear　little　inhibition　of　HIV-1　integrase.　(c)　2010　Elsevier　Ltd.　All　rights　reserved.