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Abstract:
Previous studies of young people have revealed that the left dorsolateral prefrontal cortex (DLPFC) plays an important role in inductive reasoning. An fMRI experiment was performed in this study to examine whether the left DLPFC was involved in inductive reasoning of MCI patients and normal agings, and whether the activation pattern of this region was different between MCI patients and normal agings. The fMRI results indicated that MCI patients had no difference from normal agings in behavior performance (reaction time and accuracy) and the activation pattern of DLPFC. However, the BOLD response of the DLPFC region for MCI patients was weaker than that for normal agings, and the functional connectivity between the bilateral DLPFC regions for MCI patients was significantly higher than for normal agings. Taken together, these results indicated that DLPFC plays an important role in inductive reasoning of agings, and the functional abnormity of DLPFC may be an earlier marker of MCI before structural alterations.
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Source :
SCIENCE IN CHINA SERIES C-LIFE SCIENCES
ISSN: 1006-9305
Year: 2009
Issue: 8
Volume: 52
Page: 789-795
JCR Journal Grade:3
CAS Journal Grade:1
Cited Count:
WoS CC Cited Count: 40
SCOPUS Cited Count: 42
ESI Highly Cited Papers on the List: 0 Unfold All
WanFang Cited Count:
Chinese Cited Count:
30 Days PV: 3
Affiliated Colleges: