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Author:

罗云敬 (罗云敬.) (Scholars:罗云敬) | GAO Da-yuan (GAO Da-yuan.) | WEI Hua-chen (WEI Hua-chen.)

Abstract:

Polycyclic aromatic hydrocarbons (PAHs),which constitute a major class of environmental pollu tants are posing a threat to human health. Benzopyrene,an index of PAH levels omnipresent in the everyday environment ,becomes toxic only when being metabolically and/or photo-activated,i. e. ,in the pres ence of UV light. Free radicals such as superoxide anions (''O2),hydrogen peroxide (H2O2),hydroxyl radicals (''OH) and singlet oxygen (1O2) are involved in carcinogenesis. Wei CE etc[1] studied the effects of different scavengers of active oxygen species (superoxide dismutase,catalase,mannitol and dimethyfu ran) on promoting B[a]P mutagenicity. Bryla P ete[2] investigated the roles of several ROS scavengers in the oxidation and binding of B[a]P to calf thymus DNA using the 32p-postlabeling assay.

Keyword:

代谢产物 aromatic hydrocarbons human health 氧化损伤 苯并 calf thymus DNA singlet oxygen 自由基 FREE RADICALS active oxygen species

Author Community:

  • [ 1 ] [罗云敬]北京工业大学
  • [ 2 ] [GAO Da-yuan]美国纽约大学
  • [ 3 ] [WEI Hua-chen]美国纽约大学

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Source :

广西师范大学学报(自然科学版)

ISSN: 1001-6600

Year: 2003

Issue: z6

Volume: 21

Page: 146-148

Cited Count:

WoS CC Cited Count: 0

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count: -1

Chinese Cited Count:

30 Days PV: 8

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