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Author:

Qiao, A (Qiao, A.) | Liu, YJ (Liu, YJ.) (Scholars:刘有军) | Li, SY (Li, SY.) | Zhao, H (Zhao, H.)

Indexed by:

Scopus SCIE PubMed

Abstract:

The Coronary Artery Bypass Graft (CABG) yields excellent results and remains the modern standard of care for treatment of occlusive disease in the cardiovascular system. However, the development of anastomotic Intimal Hyperplasia (IH) and restenosis can compromise the medium-and-long term effects of the CABG. This problem can be correlated with the geometric configuration and hemodynamics of the bypass graft. A novel geometric configuration was proposed for the CABG with two symmetrically implanted grafts for the purpose of improving the hemodynamics. Physiological blood flows in two models of bypass grafts were simulated using numerical methods. One model was for the conventional bypass configuration with a single graft (1-way model); the other model was for the proposed bypass configuration with two grafts (2-way model). The temporal and spatial distributions of hemodynamics, such as flow patterns and Wall Shear Stress (WSS) in the vicinity of the distal anastomoses, were analyzed and compared. Calculation results showed that the 2-way model possessed favorable hemodynamics with uniform longitudinal flow patterns and WSS distributions, which could decrease the probability of restenosis and improve the effect of the surgical treatment. Concerning the limitations of the 2-way bypass grafts, it is necessary to perform animal experiments to verify the viability of this novel idea for the CABG.

Keyword:

anastomosis intimal hyperplasia restenosis hemodynamics cardiovascular system geometric configuration CABG

Author Community:

  • [ 1 ] Beijing Univ Technol, Beijing 100022, Peoples R China
  • [ 2 ] 202 Hosp, Liaoning 110003, Peoples R China
  • [ 3 ] Shantou Univ, Coll Med, Guangdong 515031, Peoples R China

Reprint Author's Address:

  • [Qiao, A]Beijing Univ Technol, Beijing 100022, Peoples R China

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Source :

JOURNAL OF BIOLOGICAL PHYSICS

ISSN: 0092-0606

Year: 2005

Issue: 2

Volume: 31

Page: 161-182

1 . 8 0 0

JCR@2022

ESI Discipline: BIOLOGY & BIOCHEMISTRY;

JCR Journal Grade:4

Cited Count:

WoS CC Cited Count: 13

SCOPUS Cited Count: 20

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 10

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