The　microorganisms　and　natural　organic　matters　(NOM)　in　the　water　significantly　threaten　the　health　of　human　being,　thus,　it　is　an　emerging　demand　for　removal　of　those　pollutes　via　the　cost-efficient　ultrafiltration　technique.　Non-solvent　induced　phase　separation　(NIPS)　is　the　most　frequently　employed　method　for　preparing　ultrafiltration　membrane　in　industry,　however,　the　intrinsic　weaknesses　of　porous　polymeric　membranes,　e.g.　weak　mechanical　property,　foulants　adsorption,　and　low-resistance　to　acidic/basic　conditions,　greatly　hamper　their　applications.　Thus,　novel　polymer　materials　are　required　to　tackle　the　issues.　In　this　study,　we　used　a　novel　polymer,　polysulfate　(PSE)　and　adopted　it　for　preparing　ultrafiltration　membrane　via　NIPS　approach.　The　phase　inversion　process　of　the　PSE　casting　membrane　was　comprehensively　studied　by　choosing　different　solvents　and　water　as　coagulation　bath.　The　top　surface　(TS)　pore　size　of　the　resultant　membranes　was　tailored　by　changing　the　solvent　or　tuning　the　polymer　concentration,　reaching　as　small　as　10　nm　with　a　porosity　of　82.6　+/-　0.9%.　The　ultrafiltration　performance　of　the　optimized　membrane　outperforms　most　of　the　polymeric　membranes,　which　shows　both　high　flux　of　135.8　+/-　10.7　LMH　and　rejection　efficiency　of　99.1　+/-　0.83%　for　100　ppm　HA　aqueous　solution.　Furthermore,　the　prepared　membrane　also　owns　antifouling　and　acid/alkaline-resistance　characters,　which　endow　the　PSE　membrane　with　great　promise　in　the　future　industrially　ultrafiltration　applications.