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Author:

Zhao, Yu (Zhao, Yu.) | Yao, Zhijun (Yao, Zhijun.) | Zheng, Weihao (Zheng, Weihao.) | Yang, Jing (Yang, Jing.) | Ding, Zhijie (Ding, Zhijie.) | Li, Mi (Li, Mi.) (Scholars:栗觅) | Lu, Shengfu (Lu, Shengfu.)

Indexed by:

CPCI-S

Abstract:

Mild cognitive impairment (MCI) is a transition stage between normal aging and dementia. Brain network has been proven to occupy an important role in the study of differences in Alzheimer's disease (AD) and MCI. However, there is little knowledge about individual metabolic network abnormities which might be sensitive features in the prediction of MCI progression. In this paper, we constructed the individual metabolic network based on longitudinal Fluorodeoxyglucose positron emission tomography (FDG-PET) of 33 progress MCI (pMCI) patients and 46 stable MCI (sMCI) patients from the Alzheimer's disease Neuroimaging Initiative (ADNI). Firstly, PET images of each time point are normalized with the Yakushev normalization procedure and registered to the Brainnetome Atlas (BNA) template. Then the combination of rough distance and precision distance is utilized for accurate evaluation of between-region dissimilarity and calculated the correlation coefficient of the network. Finally, correlative feature selected by Lasso shows a significant promotion in classification performance compare with the metabolic intensity, achieving an accuracy of 89.9% and area under the receiver operating characteristic curve of 0.892. What's more, the combination of multi time points also suggests a better classification result than single time point. This finding may predict disease course in individuals with mild cognitive impairment.

Keyword:

Mild cognitive impairment FDG-PET Classification Individual metabolic network Longitudinal

Author Community:

  • [ 1 ] [Zhao, Yu]Lanzhou Univ, Gansu Prov Key Lab Wearable Comp, Sch Informat Sci & Engn, Lanzhou, Gansu, Peoples R China
  • [ 2 ] [Yao, Zhijun]Lanzhou Univ, Gansu Prov Key Lab Wearable Comp, Sch Informat Sci & Engn, Lanzhou, Gansu, Peoples R China
  • [ 3 ] [Zheng, Weihao]Lanzhou Univ, Gansu Prov Key Lab Wearable Comp, Sch Informat Sci & Engn, Lanzhou, Gansu, Peoples R China
  • [ 4 ] [Yang, Jing]Lanzhou Univ, Hosp 2, Lanzhou, Gansu, Peoples R China
  • [ 5 ] [Ding, Zhijie]Tianshui City Psychiat Hosp, Tianshui, Peoples R China
  • [ 6 ] [Li, Mi]Beijing Univ Technol, Int WIC Inst, Beijing, Peoples R China
  • [ 7 ] [Lu, Shengfu]Beijing Univ Technol, Int WIC Inst, Beijing, Peoples R China

Reprint Author's Address:

  • [Yao, Zhijun]Lanzhou Univ, Gansu Prov Key Lab Wearable Comp, Sch Informat Sci & Engn, Lanzhou, Gansu, Peoples R China

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Source :

2017 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM)

ISSN: 2156-1125

Year: 2017

Page: 1894-1899

Language: English

Cited Count:

WoS CC Cited Count: 4

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 6

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