The　parametric　image　of　Volume　Transfer　Coefficient　(K-trans)　in　MRI　has　been　used　to　guide　image　reconstruction　of　Near-Infrared　Spectral　Tomography　(NIRST).　The　image　reconstraction　used　direct　regularization,　in　which　no　segmentation　has　been　involved.　A　total　of　24　patients　were　involved　in　this　study　and　the　reconstructed　results　show　that　the　tumor　total　hemoglobin　(HbT)　contrast　could　be　used　to　differentiate　the　malignant　from　the　benign　cases　(p-value=0.018).　The　addition　of　the　MRI　information　allows　more　accurate　and　definitive　HbT　values　from　the　NIRST.