The　key　to　the　research　of　progressive　structural　collapse　is　to　perform　an　in-depth　investigation　into　the　structural　collapse　mechanism　at　the　onset　of　structural　component　failure　due　to　accidental　events　and　the　demand　of　progressive　collapse　resistance　for　the　remaining　substructures.　According　to　existing　research　findings,　both　beams　and　floors　are　important　anti-progressive　structural　collapse　components.　However,　the　most　common　available　methods　for　analyzing　progressive　collapse　adopt　the　empirical　coefficient　assumption,　which　lacks　the　theoretical　basis　and　neglects　the　contribution　of　floor　resistance.　This　assumption　leads　to　discrepancies　between　design　and　practice　and　causes　unnecessary　construction　costs.　This　paper　builds　the　resistance-deformation　theoretical　framework　for　the　entire　progressive　collapse　of　framed　structures　under　an　interior　column　failure　scenario　based　on　yield　line　theory,　where　the　contribution　of　floor　resistance　in　the　structural　collapse　is　taken　into　consideration.　By　comparing　experimental　results　to　a　finite　element　model,　the　simplified　models　are　validated　from　aspects　of　both　experimental　and　numerical　simulations.　To　further　validate　the　model,　a　set　of　beam-slab　progressive　collapse　tests　were　designed　in　accordance　with　the　Code　for　Design　of　Concrete　Structures.　Finally,　simplified　models　accounting　for　floor　resistance　in　the　load-carrying　and　deformation　capacities　of　RC　structures　to　resist　progressive　collapse　were　developed　to　provide　a　quantitative　estimation　for　practical　applications　in　the　design　of　frame　structures.