The　interference　screw　made　of　bioabsorbable　polymers　has　been　widely　used　in　bone　tissue　engineering.　Among　the　various　ranges　of　polymer　materials,　the　composite　of　polylactic　glycolic　acid　(PLGA)　and　β-tricalcium　phosphate　(β-TCP)　exerts　high　performance　of　biocompatibility　and　bioabsorption　for　the　knee　fixation　and　reconstruction　surgery.　The　purpose　of　this　research　is　to　first　investigate　the　influence　of　screw　thread　geometry　on　the　mechanical　properties　of　the　biocomposites　interference　screw　made　of　PLGA/β-TCP　composite.　Three　biocomposite　interference　screws　with　different　thread　designs　were　compared　in　terms　of　the　maximum　insertion　torque　and　pullout　force　via　numerical　analysis.　It　was　found　that　the　thread　design　with　modified　pitch　failed　to　improve　the　ease　of　insertion　into　the　bone　tunnel　and　resistance　of　removal.　Although　the　modified　thread　angle　type　enhanced　the　pull-out　strength,　the　higher　insertion　torque　and　strain　energy　density　(SED)　exerted　on　the　bone　made　it　was　easy　to　break　during　the　insertion　process　and　enlarge　the　bone　tunnel.　Then,　based　on　the　optimal　design　of　the　screw,　in-vitro　degradation　experiment　over　26　weeks　was　conducted　to　investigate　the　degradation　kinetics　and　evaluate　the　mechanical　properties　of　the　PLGA/β-TCP　interference　screw.　The　in　vitro　degradation　analysis　revealed　that　the　molecular　weight　residual　rate　and　degradation　time　presented　a　linear　negative　correlation　within　0　to　16　weeks　and　the　degradation　rate　was　significantly　accelerated　after　16　weeks.　However,　it　didn＇t　exhibit　any　differences　in　mass　loss　with　the　degradation　time,　which　indicated　that　the　material　can　still　keep　the　shape　in　half　a　year.　In　other　words,　the　interference　screw　made　of　PLGA/β-TCP　composite　can　meet　the　requirements　of　clinical　use　and　has　a　certain　degree　of　safety.　©　2020