In　this　research,　a　one-pot　prepared　modified　sludge　bio-hydrochar　(IBHC)　was　prepared　to　activate　persulfate　(PS)　for　the　degradation　of　tetracycline　(TC)　antibiotic.　The　obtained　IBHC　bearing　defect　structure,　dispersed　iron　and　large　amounts　of　surface　organic　functional　groups,　acts　as　an　outstanding　modified　biomass　carbonaceous　material　for　catalyzing　PS　to　improve　the　removal　efficiency　of　TC　as　high　as　99.72%.　The　IBHC　+　PS　system　can　remove　TC　effectively　with　a　relative　low　IBHC　dosage　(0.2　g.L-1),　limited　PS　consumption　(5　mmol.L-1)　and　wide　pH　values　(2-10).　In　addition,　the　degradation　of　TC　still　keep　in　94.70%　after　5　rounds　reuse　proving　that　IBHC　possesses　excellent　stability　and　practicability.　During　the　activation,　both　SO4　center　dot-　and　center　dot　OH　were　generated　and　the　contribution　of　each　component　on　the　TC　degradation　in　IBHC　+　PS　system　was　explored.　Furthermore,　the　degradation　pathways　of　TC　were　proposed　based　on　the　results　of　LC-MS.　(C)　2020　Elsevier　Ltd.　All　rights　reserved.