The　sliding-rolling　mixed　motion　behavior　degrades　the　ball　screw＇s　precision　at　different　levels.　Based　on　the　sliding-rolling　mixed　motion　between　ball　and　screw/nut　raceway,　the　ball　screw＇s　precision　loss　considering　different　given　axial　loading　and　rotational　speed　working　conditions　was　investigated.　Since　creep　and　lubrication　relate　to　sliding　and　rolling　motion　wear,　the　creep　and　lubrication　characteristics　are　analyzed　under　different　working　conditions.　Besides,　the　precision　loss　was　calculated　considering　the　sole　influence　of　sliding　behavior　between　ball　and　screw　and　compared　with　the　results　from　other　current　models.　Finally,　research　on　precision　loss　owing　to　the　sliding-rolling　mixed　motion　behavior　was　realized　under　given　working　conditions,　and　suitable　wear　tests　were　carried　out.　The　analytical　results　of　precision　loss　are　in　good　agreement　with　the　experimental　test　conclusions,　which　is　conducive　to　better　predicting　the　law　of　precision　loss　in　stable　wear　period.