A　transgenic　acute　promyelocytic　leukemia　(APL)　murine　model　established　by　Michael　Bishop　by　cloning　a　human　PML-RAR　alpha　cDNA　into　the　hMRP8　expression　cassette　has　been　widely　used　in　the　all-trans　retinoid　acid　and　arsenic　preparations　for　the　research　of　APL.　However,　in　the　existing　literature,　the　data　of　regularity　and　characteristics　of　the　pathogenesis　of　this　model　were　still　missing,　which　hinder　the　development　of　many　studies,　especially　application　of　new　technologies　such　as　single-cell　sequencing.　Therefore,　in　this　article,　we　have　made　up　this　part　of　the　missing　data　using　an　improved　APL　murine　model.　We　clarified　the　effects　of　different　inoculation　doses　on　the　onset　time,　latency,　morbidity,　life　span,　and　proportion　of　APL　cells　in　peripheral　blood　(PB),　spleen,　bone　marrow,　and　so　on.　The　relationship　between　the　proportion　of　APL　cells　in　the　bone　marrow,　spleen,　and　PB　and　organ　histological　changes　was　also　revealed.　These　results　were　a　supplement　and　refinement　of　this　APL　model.　It　would　add　to　the　knowledge　base　of　the　field　and　aid　in　ensuring　that　accurate　models　are　used　for　directed　interventions.　It　also　provides　a　great　convenience　for　the　researchers　who　will　carry　out　similar　research.