DMAP-Catalyzed One-Pot Synthesis of Quinazoline-2,4-diones from 2-Aminobenzamides and Di-tert-butyl Dicarbonate - Details

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Abstract：

The　one-pot　synthesis　of　quinazoline-2,4-diones　was　developed　in　the　presence　of　4-dimethylaminopyridine　(DMAP)　by　metal-free　catalysis.　The　commercially　available　(Boc)(2)O　acted　as　a　key　precursor　in　the　construction　of　the　2-position　carbonyl　of　quinazolinediones.　The　p-methoxybenzyl　(PMB)-activated　hetero-　cyclization　could　smoothly　proceed　at　room　temperature　instead　of　the　microwave　condition.　This　strategy　is　compatible　with　a　variety　of　substrates　with　different　functional　groups.　Furthermore,　this　protocol　was　utilized　to　smoothly　prepare　Zenarestat　with　a　total　yield　of　70%.

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[ 1 ] [Li, Peng]Peking Union Med Coll & Chinese Acad Med Sci, Beijing Key Lab Act Subst Discovery & Druggabil E, Inst Mat Med, Beijing 100050, Peoples R China
[ 2 ] [Qin, Rongfei]Peking Union Med Coll & Chinese Acad Med Sci, Beijing Key Lab Act Subst Discovery & Druggabil E, Inst Mat Med, Beijing 100050, Peoples R China
[ 3 ] [Li, Gang]Peking Union Med Coll & Chinese Acad Med Sci, Beijing Key Lab Act Subst Discovery & Druggabil E, Inst Mat Med, Beijing 100050, Peoples R China
[ 4 ] [Huang, Haihong]Peking Union Med Coll & Chinese Acad Med Sci, Beijing Key Lab Act Subst Discovery & Druggabil E, Inst Mat Med, Beijing 100050, Peoples R China
[ 5 ] [Li, Peng]Peking Union Med Coll & Chinese Acad Med Sci, Chinese Acad Med Sci, Key Lab AntiDR TB Innovat Drug Res, Inst Mat Med, Beijing 100050, Peoples R China
[ 6 ] [Qin, Rongfei]Peking Union Med Coll & Chinese Acad Med Sci, Chinese Acad Med Sci, Key Lab AntiDR TB Innovat Drug Res, Inst Mat Med, Beijing 100050, Peoples R China
[ 7 ] [Li, Gang]Peking Union Med Coll & Chinese Acad Med Sci, Chinese Acad Med Sci, Key Lab AntiDR TB Innovat Drug Res, Inst Mat Med, Beijing 100050, Peoples R China
[ 8 ] [Huang, Haihong]Peking Union Med Coll & Chinese Acad Med Sci, Chinese Acad Med Sci, Key Lab AntiDR TB Innovat Drug Res, Inst Mat Med, Beijing 100050, Peoples R China
[ 9 ] [Chen, Hui]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing Key Lab Environm & Viral Oncol, Beijing 100124, Peoples R China
[ 10 ] [Yan, Hong]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing Key Lab Environm & Viral Oncol, Beijing 100124, Peoples R China

Reprint Author's Address：

李港
[Li, Gang]Peking Union Med Coll & Chinese Acad Med Sci, Beijing Key Lab Act Subst Discovery & Druggabil E, Inst Mat Med, Beijing 100050, Peoples R China;;[Huang, Haihong]Peking Union Med Coll & Chinese Acad Med Sci, Beijing Key Lab Act Subst Discovery & Druggabil E, Inst Mat Med, Beijing 100050, Peoples R China;;[Li, Gang]Peking Union Med Coll & Chinese Acad Med Sci, Chinese Acad Med Sci, Key Lab AntiDR TB Innovat Drug Res, Inst Mat Med, Beijing 100050, Peoples R China;;[Huang, Haihong]Peking Union Med Coll & Chinese Acad Med Sci, Chinese Acad Med Sci, Key Lab AntiDR TB Innovat Drug Res, Inst Mat Med, Beijing 100050, Peoples R China

Email：

ligang@imm.ac.cn |
joyce@imm.ac.cn

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ACS OMEGA

ISSN： 2470-1343

Year： 2020

Issue： 16

Volume： 5

Page： 9614-9623

4 . 1 0 0

JCR@2022

Cited Count：

WoS CC Cited Count： 20

SCOPUS Cited Count： 21

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 17

Affiliated Colleges：

化学与生命科学学院本学院/部未明确归属的数据

材料科学与工程学院本学院/部未明确归属的数据

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