:the　rapid　detection　of　antibiotics　in　agricultural　productsis　of　great　significance.　In　this　work,　two　stablefluorescent　metal-organic　frameworks　(MOFs),　BUT-178　and　BUT-179,　are　synthesizedand　used　to　detect　tetracycline　antibiotics.　Among　them,　BUT-179exhibits　better　performance　in　the　detection　of　different　tetracyclineantibiotics　in　water　and　eggs.　The　limits　of　detection　of　BUT-179　towardtetracycline,　aureomycin,　oxytetracycline,　and　doxycycline　all　reach　thenanomolar　level.　Furthermore,　the　cycling　tests　confirm　that　BUT-179can　be　easily　recovered　and　repeatedly　used　without　an　obviousperformance　loss.　This　work　demonstrates　the　excellent　applicationpotential　of　MOFs　for　food　safety,　especially　thefluorescence　detectionof　antibiotics　in　foods