Due　to　the　internal　fiber　structure　and　extrusion　in　the　assembly　process　of　fuel　cell,　the　gas　diffusion　layer　presents　various　characteristics　in　different　directions,　which　makes　transmission　coefficients　show　anisotropy　and　affects　overall　cell　performance.　In　order　to　predict　the　performance　and　understand　influence　of　coefficient　anisotropy,　a　more　accurate　model　should　be　found.　In　this　work,　a　three-dimensional,　non-isothermal,　twophase　agglomerate　model　considering　the　porosity　difference　of　gas　diffusion　layer　under　rib　and　channel　is　established.　The　influence　of　conductivity,　thermal　conductivity,　permeability　and　diffusion　coefficient　on　overall　cell　performance　is　investigated　by　numerical　simulation.　The　results　show　that　diffusion　coefficient　anisotropy　should　be　considered　during　numerical　simulation　when　cell　voltage　is　less　than　or　equals　to　0.5　V.　The　conductivity　anisotropy　should　be　taken　into　account　when　cell　voltage　is　greater　than　0.5　V.　Compared　with　isotropic　model,　electron　potential　in　cathode　side　increases　and　current　density　decreases　for　conductivity　anisotropy　model,　cell　temperature　in　thermal　conductivity　anisotropy　model　is　higher,　dissolved　and　liquid　water　content　in　permeability　anisotropy　model　increase,　local　current　density　in　diffusion　coefficient　anisotropy　model　is　lower.　The　influence　of　each　coefficient　on　cell　characteristic　is　various　at　different　voltages.