In　this　study,　we　prepared　a　streptavidin　magnetic　bead　based　on　graphene-coated　iron　nitride　magnetic　beads　(G@FeN-MB)　and　tried　to　use　it　for　the　enrichment　of　severe　acute　respiratory　syndrome　coronavirus-2　(SARS-CoV-2).　The　outer　shell　of　our　magnetic　bead　was　wrapped　with　multiple　graphene　sheets,　and　there　is　no　report　on　the　application　of　graphene　to　the　magnetic-bead-coating　material.　First,　the　graphene　shell　of　G@FeN-MB　was　oxidized　by　a　modified　Hummer　method　so　as　to　generate　the　carboxyl　groups　required　for　the　coupling　of　streptavidin　(SA)　on　the　surface　of　the　magnetic　beads.　X-ray　photoelectron　spectroscopy　(XPS),　Raman　spectroscopy,　Fourier　transform　infrared　spectroscopy　(FTIR),　and　transmission　electron　microscopy　(TEM)　were　used　to　characterize　the　oxidized　G@FeN-MB　(GO@FeN-MB).　Streptavidin　was　then　linked　to　the　surface　of　the　GO@FeN-MB　by　coupling　the　amino　of　the　streptavidin　with　the　carboxyl　on　the　magnetic　beads　by　carbodiimide　method;　thus,　the　streptavidin　magnetic　beads　(SAMBs)　were　successfully　prepared.　To　prove　the　practicality　of　the　SAMBs,　biotinylated　SARS-CoV-2　S1　antibody　was　linked　with　it　to　respectively　capture　SARS-CoV-2　Spike-protein-coupled　polystyrene　beads　(S-PS)　and　pseudovirus　with　S-protein　expressed.　Microplate　reader　and　fluorescence　microscope　results　show　that　the　SAMBs　can　effectively　enrich　viruses.　In　conclusion,　the　preparation　of　SAMBs　with　G@FeN-MB　is　feasible　and　has　potential　for　application　in　the　field　of　virus　enrichment.