In　precast　reinforced　concrete　frame　structures,　beam-column　joints　suffer　severe　damage　under　large　deformations,　which　may　significantly　influence　their　performance　in　resisting　progressive　collapse.　A　static　progressive　collapse　test　was　conducted　on　one　conventional　reinforced　concrete　beam-column　substructure　(RC)　and　four　precast　reinforced　concrete　beam-column　substructures　with　wet　connections　(PCWC).　A　quasiuniformly　distributed　load　was　applied　to　the　substructures　to　simulate　gravity　loads.　The　first　group　of　PCWC　specimens　consisted　of　two　specimens　with　different　layouts　of　mechanical　sleeves,　in　which　the　beam　and　column　reinforcements　were　connected　through　mechanical　sleeves　and　grout-filled　coupling　sleeves,　respectively.　In　the　second　group　of　PCWC　specimens,　the　beam　and　column　reinforcements　were　joined　through　a　90　degrees　bend　anchorage　and　lapping　in　grout-filled　holes,　respectively.　In　one　of　the　PCWC　specimens　in　this　group,　unbonded　prestressed　strands　(UPS)　were　also　adopted.　For　the　first　group,　premature　failure　of　the　mechanical　sleeve　connections　occurred,　which　reduced　the　collapse　resistances　of　the　PCWC　specimens　compared　with　that　of　the　RC　specimen.　For　the　second　group,　the　damage　mode　and　collapse　resistance　of　the　specimen　without　UPS　were　similar　to　those　of　the　RC　specimen.　Furthermore,　the　collapse　resistance　of　the　specimen　with　UPS,　which　generated　additional　axial　force　along　the　beam,　was　greater　than　that　of　the　RC　specimen.　The　connections　of　the　column　reinforcements　in　all　PCWC　specimens　exhibited　robustness　under　large　deformations　of　progressive　collapse,　even　though　large　horizontal　deformations　and　slips　along　the　grout-layer　were　observed　in　the　specimen　with　UPS.　An　analytical　model　was　then　developed　to　study　the　collapse　resistances　of　the　specimens,　particularly　the　contributions　of　the　compressive　arch　action　and　the　catenary　action.　Finally,　numerical　simulations　were　used　to　optimize　the　configurations　of　PCWC　connections,　namely　the　arrangements　of　the　mechanical　sleeves,　levels　of　the　UPS,　and　strength　of　the　cast-in-situ　concrete,　to　improve　their　performance　in　resisting　progressive　collapse.