Direct　conversion　of　methane　into　value-added　chemicals,　such　as　methanol　under　mild　conditions,　is　a　promising　route　for　industrial　applications.　In　this　work,　atomically　dispersed　Rh　on　TiO2　suspended　in　an　aqueous　solution　was　used　for　the　oxidation　of　methane　to　methanol.　Promoted　by　copper　cations　(as　co-catalyst)　in　solution,　the　catalysts　exhibited　high　activity　and　selectivity　for　the　production　of　methanol　using　molecular　oxygen　with　the　presence　of　carbon　monoxide　at　150　degrees　C　with　a　reaction　pressure　of　31　bar.　Millimole　level　yields　of　methanol　were　reached　with　the　selectivity　higher　than　99　%　using　the　Rh/TiO2　catalysts　with　the　promotion　of　the　copper　cation.　CO　was　the　reductive　agent　to　generate　H-2　from　H2O,　which　led　to　the　formation　of　H2O2　through　the　reaction　of　H-2　and　O-2.　Atomically　dispersed　Rh　activated　the　C-H　bond　in　CH4　and　catalyzed　the　oxidation　using　H2O2.　Copper　cations　maintained　the　low-valence　state　of　Rh.　Moreover,　copper　acted　as　a　scavenger　for　suppressing　the　overoxidation,　thus　leading　to　the　high　selectivity　of　methanol.