Zwitterionic　groups　are　conducive　to　improve　the　antifouling　performance　and　water　permeability　of　nanofiltration　membranes　because　of　the　excellent　hydrophilicity　and　charged　property.　However,　the　transport　of　zwitterionic　monomers　during　interfacial　polymerization　process　is　much　slower　than　the　reaction,　leading　to　form　many　defects　in　the　separation　layer.　In　this　study,　phase　transfer　catalysts　were　used　to　intensify　the　interfacial　mass　transfer　of　zwitterionic　amine　monomers　for　fabricating　polyamide　thin-film　composite　nanofiltration　membranes.　The　transport　process　was　explored　by　measuring　the　diffusion　kinetics　of　monomers　to　regulate　the　structures　and　properties　of　zwitterionic　membranes.　Consequently,　low　concentration　of　N-aminoethyl　piperazine　propane　sulfonate　(AEPPS)　as　aqueous　monomer　could　be　used　to　prepare　membranes　with　excellent　nanofiltration　performance.　When　the　concentration　of　AEPPS　was　as　low　as　1　w/v%,　the　as-prepared　zwitterionic　membrane　possessed　a　pure　water　flux　of　10.6　L　m(-2)　h(-1)　bar(-1)　with　a　high　erythromycin　retention　of　91.7%　and　a　low　NaCl　retention　of　7.3%,　which　exhibited　great　application　potential　in　the　separation　of　monovalent　salt/antibiotics.　Moreover,　the　flux　recovery　ratio　of　the　zwitterionic　membrane　was　still　maintained　at　similar　to　96.5%　after　undergoing　twice　fouling-rinse　experiments　of　bovine　serum　albumin,　exhibiting　exceptional　antifouling　performance.