In　order　to　realize　the　real-time　portability　monitoring　of　human　blood　oxygen,　a　portable　low-power　blood　oxygen　detection　device　was　designed　and　studied.　The　device　adopts　STM32　microcontroller　as　the　main　control　chip　and　data　processing　unit,　AFE4950　blood　oxygen　sensing　chip　as　the　data　acquisition　chip,　and　controls　the　STM32　microcontroller　through　software　programming　design,　so　as　to　realize　the　functions　of　AFE4950　sensor,　OLED　display　circuit,　Bluetooth　transmission　circuit　and　USB　debugging　circuit,　and　real-time　dynamic　monitoring　of　human　blood　oxygen　concentration.　The　design　has　good　stability,　low　design　cost　and　small　size　and　easy　to　carry,　providing　a　new　idea　for　blood　oxygen　detection　in　the　field　of　mobile　medicine.　©　2022　IEEE.