HAp　has　drawn　great　attention　in　recent　years　for　its　similarity　to　the　inorganic　component　of　bone.　However,　the　application　is　limited　due　to　its　poor　shape　ability,　low　mechanical　property,　and　biodegradability.　In　this　work,　silica-doped　HAp　ceramic　scaffolds　are　3D　printed　with　a　natural　optimized　trabecular　bone　structure.　Specifically,　with　the　addition　of　silica,　composite　scaffolds　sintered　at　1200　°C　exhibit　a　decrease　of　pores　and　increase　of　grain　size,　yielding　a　compressive　strength　increased　from　3.93±0.75　MPa　to　12.94±0.70　MPa,　comparable　to　the　trabecular　bone.　Results　of　XRD　and　SEM　illustrate　that　the　addition　of　silica　promotes　the　formation　of　the　bioactive　TCP　phase.　Biological　characterization　in　SBF　illustrates　that　the　in　vitro　bioactivity　of　the　silica-doped　scaffolds　is　superior　to　that　of　the　pure　HAp,　and　the　scaffolds　are　biodegradable.　Cytocompatibility　study　revealed　that　there　is　no　potential　cytotoxicity　for　L929　cells　on　all　groups　of　scaffolds.　Trabecular　bone　structure-mimicking　silica-doped　ceramic　scaffolds　with　high　strength　and　in　vitro　bioactive　are　developed.　The　Silica-doped　ceramic　scaffolds　can　be　tailored　to　certain　biological　response　requirements　as　a　promising　material　for　bone　defect　regeneration.　©　2022　Elsevier　Ltd　and　Techna　Group　S.r.l.