In　this　paper,　we　establish　an　efficient　numerical　model　of　water-structure-soil　systems　under　seismic　action　based　on　ABAQUS　to　analyze　the　influence　of　water-structure　and　water-soil　interaction　on　the　response　of　the　structure,　soil　and　water　under　different　water　depths.　Under　the　action　of　horizontal　ground　motions,　the　results　show　that　the　influence　of　the　water-soil　interaction　on　the　response　of　the　system　is　much　less　than　that　of　the　water-structure　interaction,　and　that　the　influence　on　the　response　of　the　structure,　soil　and　water　is　negligible.　Under　the　action　of　vertical　ground　motions,　the　effect　of　water-structure　interaction　on　system　response　is　much　less　than　that　of　water-soil　interaction,　and　that　the　water-structure　interaction　has　little　influence　on　the　system　response.　Therefore,　only　the　water-soil　dynamic　interaction　needs　to　be　considered　in　theoretical　simplification　analysis.　Copyright　©2022　Engineering　Mechanics.　All　rights　reserved.