Based　on　the　Rayleigh-Love　rod　model　and　three-dimensional　continuum　theory　and　considering　the　transverse　inertia　effect　of　piles　and　the　vertical　wave　effect　of　soil,　an　interaction　analysis　model　for　the　longitudinal　vibration　of　a　large-diameter　pipe　pile　in　three-dimensional　axisymmetric　radial　inhomogeneous　viscous　damping　soil　is　established.　By　utilizing　Laplace　transforms　and　complex　stiffness　transfer　method,　the　interaction　expression　at　the　interface　of　pile　and　soil　is　also　derived.　Under　the　assumption　of　perfectly　coupled　condition　between　the　pile　and　the　soil,　the　semi-analytical　solution　for　the　dynamic　response　at　the　large-diameter　pipe　pile　head　is　obtained　in　time　domain　by　using　Fourier　inversion　and　convolution　theorem.　Then,　the　present　analytical　solution　is　reduced　to　verify　its　validity　by　comparison　with　the　existing　solutions.　Finally,　an　extensive　parametric　analysis　is　conducted　to　investigate　the　effects　of　the　Poisson＇s　ratio　and　the　wave　velocity　of　the　pile　as　well　as　the　construction　disturbance　of　the　soil　on　the　dynamic　response　of　the　large-diameter　pipe　pile.　The　results　show　that:　(1)　With　increasing　the　Poisson＇s　ratio　of　the　pile　shaft,　both　the　amplitude　and　the　resonance　frequency　of　the　velocity　admittance　curve　at　the　pile　head　decrease　and　the　reflected　wave　curve　shows　obvious　oscillation　phenomenon.　(2)　Both　the　velocity　admittance　curve　at　the　pile　head　and　the　amplitude　of　reflected　signals　at　the　pile　bottom　increase　with　increasing　the　wave　velocity　of　the　pile　shaft.　(3)　When　the　transverse　inertia　effect　of　the　pile　shaft　is　considered,　the　influence　of　the　construction　disturbance　effect　on　the　dynamic　response　at　the　pile　head　is　more　significant.　(4)　By　degenerating　the　derived　solution　and　comparing　it　with　the　existing　solutions,　the　rationality　and　accuracy　of　the　solution　are　verified.　The　research　can　provide　a　reference　for　the　longitudinal　vibration　analysis　and　design　of　pile　foundations.　©　2022,　Science　Press.　All　right　reserved.