The　asymmetric　deformation　of　a　laser　beam　reflected　from　the　surface　of　a　droplet　on　a　slide　was　observed.　The　degree　of　deformation　of　the　beam　profile　in　the　incident　plane　is　related　to　the　droplet　contact　angle,　and　the　degree　of　deformation　perpendicular　to　the　incident　plane　is　related　to　the　droplet　curvature.　A　simple,　non-contact,　real-time　technique　to　measure　droplet　wetting　parameters　was　established.　The　contact　angle　and　radius　of　curvature　for　different　liquid　droplets　were　measured,　and　measurement　errors　were　in　the　sub-degree　and　sub-millimeter　orders　of　magnitude,　respectively.　The　values　obtained　for　the　contact　angle　using　the　reported　measurement　technique　compared　with　those　obtained　using　a　traditional　measurement　technique　with　an　imaging　contact　angle　meter　showed　the　reported　technique　to　be　reliable.　The　contact　angle　and　radius　of　curvature　for　four　blood　samples　were　measured　and　compared　with　those　obtained　from　blood　samples　using　a　routine　test.　For　samples　with　white　blood　cells,　hemoglobin,　and　hematocrit　exceeding　the　standard,　their　wetting　parameters　regularly　deviated　from　those　of　normal　samples.　©　2022　Author(s).