It　is　well　known　that　there　are　two　approaches　applicable　in　constructing　frames　starting　from　one　fixed　frame.　One　is　based　on　l(2)-operator　portraits　by　which,　using　a　suitable　bounded　linear　operator　on　l(2),　one　can　construct　an　arbitrary　frame　from　one　fixed　frame.　The　other　is　based　on　perturbation　that　allows　suitable　perturbing　a　frame　leaving　a　frame.　The　study　of　Hilbert-Schmidt　frames　(HS-frames)　has　interested　some　mathematicians　in　recent　years.　This　paper　addresses　l(2)-operator　portraits　and　perturbations　in　the　setting　of　HS-frames.　We　prove　that　the　portrait　of　a　HS-frame　under　a　bounded　invertible　operator　on　l(2)　is　still　a　HS-frame;　present　a　sufficient　condition　on　bounded　operators　on　l(2)　which　transform　an　l(2)-decomposable　HS-frame　into　another　HS-frame　(HS-Riesz　basis,　HS-frame　sequence　and　HS-Riesz　sequence);　and　prove　that　suitable　perturbing　a　HS-frame　sequence　(HS-Riesz　sequence)　leaves　a　HS-frame　sequence　(HS-Riesz　sequence).　Finally,　using　these　results　we　recover　some　conclusions　on　frames.