Herein,　a　degradable　silicon-based　iron-doped　nanoparticle　(Fe-MSN)　was　prepared　as　a　porous　carrier.　After　loading　the　pesticide　prochloraz　(Pro),　tannic　acid　(TA)　was　used　to　seal　the　pores　and　stabilize　the　nanocarrier　structure.　Due　to　the　enough　pore　surface　areas,　the　loading　rate　of　Pro@Fe-MSNs/TA　nanoparticles　(Nps)　was　up　to　31%.　Nps　possessed　an　excellent　acid-responsive　controlled-release　of　Pro　and　degradation　behavior　of　the　silica　wall.　Nanocarrier　could　effectively　protect　Pro　against　photodegra-dation　and　improve　the　storage　stability　of　Pro.　Pesticide　deposition　was　enhanced　by　good　wettability　and　Nps　possessed　better　inhibitory　efficacy　against　Rhizoctonia　solani.　The　biosafety　of　Nps　was　evaluated　and　showed　no　obvious　toxicological　influence　on　cells　and　zebrafish.　Furthermore,　the　pot　experiment　showed　that　nanocarriers　could　effectively　promote　the　growth　of　wheat　plants　due　to　the　rich　supply　of　metal　trace　element.　This　study　provides　a　promising　strategy　for　sustainable　crop　disease　management　to　reduce　environmental　risk.(c)　2022　The　Author(s).　Published　by　Elsevier　B.V.　This　is　an　open　access　article　under　the　CC　BY-NC-ND　license　(http://creativecommons.org/licenses/by-nc-nd/4.0/).