Background:　The　conventional　FFRct　numerical　calculation　method　uses　a　model　with　a　multi-scale　geometry　based　upon　CFD,　and　rigid　walls.　Therefore,　important　interactions　between　the　elastic　vessel　wall　and　blood　flow　are　not　routinely　considered.　Changes　in　the　resistance　of　coronary　microcirculation　during　hyperaemia　are　likewise　not　typically　incorporated　using　a　fluid-structure　interaction　(FSI)　algorithm.　It　is　likely　that　both　have　resulted　in　FFRct　calculation　errors.Objective:　In　this　study　we　incorporated　both　the　influence　of　vascular　elasticity　and　coronary　microcirculatory　structure　on　FFR,　to　improve　the　accuracy　of　FFRct　calculation.　Thus,　in　this　study,　a　physics-driven　3D-0D　coupled　model　including　fluid-structure　interaction　was　established　to　calculate　accurate　FFRct　values.Methods:　Based　upon　a　novel　geometric　multi-scale　modeling　technology,　a　FSI　simulation　approach　was　used.　A　lumped　parameter　model　(0D)　was　used　as　the　outlet　boundary　condition　for　the　3D　FSI　coronary　artery　model　to　incorporate　physiological　microcirculation,　with　bidirectional　coupling　between　the　two　models.Results:　The　accuracy,　sensitivity,　specificity,　and　both　positive　and　negative　predictive　values　of　FFRDC　calculated　based　upon　the　coupled　3D-0D　model　were　86.7,　66.7,　84.6,　66.7,　and　91.7%,　respectively.　Compared　to　the　calculated　value　using　the　basic　CFD　model　(MSE　=　5.9%,　accuracy　rate　=　80%),　the　FFRCFD　calculated　based　on　the　coupled　3D-0D　model　has　a　smaller　MSE　of　1.9%.Conclusion:　The　physics-driven　coupled　3D-0D　model　that　incorporates　fluid-structure　interactions　not　only　consider　the　influence　of　the　elastic　vessel　wall　on　blood　flow,　but　also　provides　reliable　microvascular　resistance　boundary　conditions　for　the　3D　FSI　model.　This　allows　for　a　calculation　that　is　based　upon　conditions　that　are　closer　to　the　physiological　environment,　and　thus　improves　the　accuracy　of　FFRct　calculation.　It　is　likely　that　more　accurate　information　will　provide　an　enhanced　recommendation　regarding　percutaneous　coronary　intervention　(PCI)　in　the　clinic.