The　article　selects　socioeconomic　data　related　to　146　prefecture-level　cities　included　in　nine　city　clusters　from　2014　to　2018　to　establish　a　city-level　socioeconomic　system　in　China.　A　sensitivity　analysis　of　regional　entrepreneurship　and　economic　quality　development　based　on　system　dynamics　was　conducted　to　explore　the　changes　in　regional　entrepreneurship　and　economic　quality　development　over　time　and　their　sensitivity　factors.　In　this　way,　the　dynamic　evolution　mechanism　of　the　system　can　be　portrayed,　and　the　optimization　of　the　system　can　be　achieved　through　the　coordination　of　the　factors　within　the　system.　The　article　sets　up　three　scenarios　to　explore　the　fluctuations　in　regional　entrepreneurship　and　economic　quality　development　when　three　sensitive　factors,　namely,　business　environment,　financial　services　scale,　and　innovation　environment,　change.　Findings:　There　are　differences　in　the　development　of　cities　within　city　clusters.　The　business　environment　and　high-quality　economic　development　of　the　central　cities　within　the　city　cluster　are　stronger　than　those　of　the　non-central　cities.　Therefore,　regions　should　focus　on　synergistic　development　within　city　clusters　when　formulating　related　policies.　The　variation　of　regional　entrepreneurship　development　and　economic　quality　development,　after　a　factor　in　the　system　is　changed,　is　asymmetric.　Because　the　sensitivity　of　different　urban　clusters　and　the　way　they　are　affected　by　sensitive　factors　varies,　the　state　should　pay　more　attention　to　the　adaptability　of　cities　when　formulating　corresponding　policy　measures　and　adapt　its　policy　measures　to　the　sensitivity　characteristics　of　each　region　according　to　local　conditions.