In　recent　years,　a　series　of　continuous　fabrication　technologies　based　on　digital　light　processing　(DLP)　3D　printing　have　emerged,　which　have　significantly　improved　the　speed　of　3D　printing.　However,　limited　by　the　resin　filling　speed,　those　technologies　are　only　suitable　to　print　hollow　structures.　In　this　paper,　an　optimized　protocol　for　developing　continuous　and　layer-wise　hybrid　DLP　3D　printing　mode　is　proposed　based　on　computational　fluid　dynamics　(CFD).　Volume　of　the　fluid　method　is　used　to　simulate　the　behavior　of　resin　flow　while　Poiseuille　flow,　Jacobs　working　curve,　and　Beer-Lambert　law　are　used　to　optimize　the　key　control　parameters　for　continuous　and　layer-wise　printing.　This　strategy　provides　a　novel　simulation-based　method　development　scenario　to　establish　printing　control　parameters　that　are　applicable　to　arbitrary　structures.　Experiments　verified　that　the　printing　control　parameters　obtained　by　simulations　can　effectively　improve　the　printing　efficiency　and　the　applicability　of　DLP　3D　printing.