Catalytic　performance　and　moisture　and　sulfur　dioxide　resistance　are　important　for　a　catalyst　used　for　the　oxidation　of　volatile　organic　compounds　(VOCs).　Supported　noble　metals　are　active　for　VOC　oxidation,　but　they　are　easily　deactivated　by　water　and　sulfur　dioxide.　Hence,　it　is　highly　desired　to　develop　a　catalyst　with　high　performance　and　good　moisture　and　sulfur　dioxide　resistance　in　the　oxidation　of　VOCs.　In　this　work,　we　first　adopted　the　hydrothermal　method　to　synthesize　a　V2O5-TiO2　composite　support,　and　then　employed　the　polyvinyl　alcohol　(PVA)-protecting　NaBH4　reduction　strategy　to　fabricate　xPdPt(y)/V2O5-TiO2　catalysts　(x　and　y　are　the　PdPty　loading　(0.41,　0.46,　and　0.49　wt%)　and　Pt/Pd　molar　ratio　(2.10,　0.85,　and　0.44),　respectively;　the　corresponding　catalysts　are　denoted　as　0.46PdPt(2.10)/V2O5-TiO2,　0.41PdPt(0.85)/V2O5-TiO2,　and　0.49PdPt(0.44)/V2O5-TiO2).　Among　all　the　samples,　0.46PdPt(2.10)/V2O5-TiO2　exhibited　the　best　catalytic　activity　for　toluene　oxidation　(T-50%　=　220　degrees　C　and　T-90%　=　245　degrees　C　at　a　space　velocity　of　40,000　mL/(g　h),　apparent　activation　energy　(E-a)　=　45　kJ/mol),　specific　reaction　rate　at　230　degrees　C　=　98.6　mu　mol/(g(Pt)　s),　and　turnover　frequency　(TOFNoble　(metal))　at　230　degrees　C　=　142.2　x　10(-)(3)　s(-)(1).　The　good　catalytic　performance　of　0.46PdPt(2.10)/V2O5-TiO2　was　associated　with　its　well-dispersed　PdPt2.10　nanoparticles,　high　adsorbed　oxygen　species　concentration,　good　redox　ability,　large　toluene　adsorption　capacity,　and　strong　interaction　between　PdPty　and　V2O5-TiO2.　No　significant　changes　in　toluene　conversion　were　detected　when　5.0　vol%　H2O　or　50　ppm　SO2　was　introduced　to　the　reaction　system.　According　to　the　characterization　results,　we　can　realize　that　vanadium　is　the　main　site　for　SO2　adsorption　while　PdO　is　the　secondary　site　for　SO2　adsorption,　which　protects　the　active　Pt　site　from　being　poisoned　by　SO2,　thus　making　the　0.46PdPt(2.10)/V2O5TiO2　catalyst　show　good　sulfur　dioxide　resistance.