This　paper　investigates　the　seismic　bridge-pile-soil　system　failure　mechanisms　due　to　liquefaction-induced　lateral　spreading.　Two　large-scale　shaking　table　tests　were　performed　on　pile　groups　with　and　without　bridges　in　sloped　liquefiable　soils　overlain　by　soil　crust.　The　systems　were　subjected　to　a　weak　earthquake　signal　(Tabas　0.05　g)　and　a　strong　earthquake　signal　(Tabas　0.3　g).　Their　responses　were　recorded　in　terms　of　excess　pore　pressure,　acceleration,　and　displacement　time　histories.　The　piles　seismic　failure　mode　and　mechanism　are　described　based　on　the　obtained　results.　In　addition,　the　inertial　and　kinematic　interaction　effects　on　the　piles＇　deflection　were　evaluated.　The　results　demonstrated　that　the　bridge　had　no　significant　effect　on　the　seismic　response　of　the　pile-soil　system　under　weak　earthquakes.　Meanwhile,　the　test　model　without　a　bridge　experienced　more　significant　soil　lateral　displacement,　and　the　saturated　sand　exhibited　dilatant　behavior,　and　amplified　the　acceleration　peak　response　during　the　strong　earthquake.　Moreover,　the　liquefaction-induced　lateral　spreading　moved　the　vulnerable　position　of　the　pile　group　bridge　system　from　the　pier　bottom　to　the　pile　head,　which　changed　the　failure　mode　of　the　pile　head.　The　results　also　revealed　that,　compared　with　weak　earthquake　excitation,　the　kinematic　effect　was　significantly　enhanced,　and　the　inertia　effect　was　weakened　during　strong　earthquakes.　Moreover,　the　pile　curvature　during　both　weak　and　strong　earthquakes　was　inversely　proportional　to　the　bridge　inertial　load.