Herein,　different　heat　treatment　protocols　are　adopted　to　further　improve　the　mechanical　properties　of　the　Al-Cr-Fe-Ni-V　high-entropy　alloy　(HEA)　fabricated　by　laser　powder　bed　fusion　(LPBF)　additive　manufacturing　(AM).　The　initial　LPBF-processed　HEA　rendered　a　combination　of　high　strength　(ultimate　tensile　strength　(UTS)　of　810.93　MPa)　and　ductility　(fracture　elongation　(FE)　of　35.43%),　which　could　be　attributed　to　the　hierarchical　microstructure　with　fine　grains,　cellular　dislocation　structure,　and　L12　nano-precipitation.　When　the　annealing　temperature　is　increased　from　573　K　to　1473　K,　the　cellular　dislocation　structure　is　disappeared,　and　both　L12　and　B2　phases　are　progressively　precipitated　in　the　FCC　matrix.　Simultaneously,　the　tensile　strength　dramatically　increased　at　the　expense　of　ductility　reduced　and　LPBF-processed　HEA　demonstrated　a　high　UTS　of　1192.84　MPa　and　FE　of　15.32%　after　annealing　at　1173　K.　The　results　reveal　that　precipitation　strengthening　plays　a　significant　role　in　improving　the　mechanical　properties　of　LPBF-processed　HEAs　during　annealing.　For　instance,　L12　and　B2　precipitates　hindered　the　dislocation　movement　and,　in　turn,　enhanced　the　pinning　force　of　boundary　migration.　Moreover,　the　highly　coherent　and　low　misfit　FCC-L12　interfaces　minimized　the　strain　accumulation　due　to　the　dislocation　shear　and,　thereby,　prevented　the　crack　initiation.