With　the　acceleration　of　urbanization,　the　distance　between　the　underground　structure　and　the　aboveground　structure　is　becoming　smaller　and　smaller,　and　the　mutual　influence　between　them　during　earthquake　is　worthy　of　attention.　In　this　study,　a　three-dimensional　(3D)　finite　element　(FE)　analysis　procedure　was　verified　based　on　shaking　table　test　data　firstly.　Subsequently,　the　validated　FE　analysis　procedure　was　used　to　carry　out　an　extended　parameter　analysis　to　study　general　seismic　response　of　more　complex　aboveground　structure-soil-underground　structure　systems.　The　key　parameters,　such　as　the　height　and　number　of　aboveground　structures,　earthquake　type,　and　distance　between　underground　and　aboveground　structures,　were　considered.　It　was　found　that　the　tunnel-soil-aboveground　structure　interaction　could　effectively　affect　the　acceleration　and　deformation　response　of　both　the　ground　and　underground　structures.　With　the　increasing　height　and　number　of　aboveground　structures　and　the　decreasing　distance　between　underground　and　aboveground　structures,　the　deformation　of　the　underground　structure　tended　to　become　larger.　On　the　other　hand,　the　existence　of　underground　structure　could　effectively　reduce　the　response　of　aboveground　structure,　and　the　influencing　effect　was　found　to　be　considerably　affected　by　the　distance　between　underground　and　aboveground　structures.　The　findings　obtained　from　this　study　could　provide　useful　references　for　the　seismic　design　of　both　aboveground　and　underground　structures　in　urban　areas.