Background　It　has　been　reported　that　strict　non-pharmaceutical　measures　can　significantly　reduce　the　incidence　and　mortality　of　respiratory　and　intestinal　infectious　diseases　during　the　COVID-19　pandemic,　but　there　are　limited　reports　on　the　impact　in　terms　of　the　rates　of　zoonotic　diseases.　Methods　We　extracted　the　incidence　and　mortality　data　of　eight　notifiable　infectious　zoonotic　diseases　from　the　website　of　the　National　Health　Commission　of　the　People＇s　Republic　of　China　for　the　period　of　January　2015　to　April　2021.　Results　First,　the　overall　incidence　of　zoonotic　diseases　decreased　from　0.3714　per　100　000　in　2015-2019　to　0.2756　in　2020　(25.79%　reduction,　p＜0.001);　however,　a　dramatic　increase　in　activity　was　seen　in　2021　compared　with　2020　(0.4478　per　100　000　in　2021,　62.47%　increase,　p＜0.001).　Anthrax,　brucellosis,　leptospirosis　and　hydatid　disease　exhibited　significant　upward　trends　in　2021.　Second,　analysed　further　by　stages,　the　monthly　incidence　in　the　routine　stage　(from　May　to　December　2020)　was　much　higher　than　that　in　the　emergency　stage　of　the　COVID-19　(from　January　to　April　2020)　(55.33%　increase,　p＜0.001).　We　also　found　that　the　monthly　observed　incidence　was　significantly　lower　than　the　predicted　incidence　of　a　10.29%　reduction　in　the　emergency　stage.　Third,　no　differences　were　seen　in　mortality　between　2021　and　2020,　while　a　significant　decline　was　found　in　2020　compared　with　the　previous　5　years　(72.70%,　p＜0.001).　Conclusions　Strict　containment　and　feasible　suppression　strategies　during　the　2020　period　of　the　COVID-19　pandemic　had　positive　impacts　on　the　overall　incidence　of　zoonotic　diseases　in　China.　However,　anthrax,　brucellosis,　leptospirosis　and　hydatid　diseases　might　increase　with　the　relaxation　of　non-pharmacological　interventions　in　2021.