Autophagy,　a　cellular　lysosomal　degradation　and　survival　pathway,　supports　nutrient　recycling　and　adaptation　to　metabolic　stress　and　participates　in　various　stages　of　tumor　development,　including　tumorigenesis,　metastasis,　and　malignant　state　maintenance.　Among　the　various　factors　contributing　to　the　dysregulation　of　autophagy　in　cancer,　RNA　modification　can　regulate　autophagy　by　directly　affecting　the　expression　of　core　autophagy　proteins.　We　propose　that　autophagy　disorder　mediated　by　RNA　modification　is　an　important　mechanism　for　cancer　development.　Therefore,　this　review　mainly　discusses　the　role　of　RNA　modification-mediated　autophagy　regulation　in　tumorigenesis.　We　summarize　the　molecular　basis　of　autophagy　and　the　core　proteins　and　complexes　at　different　stages　of　autophagy,　especially　those　involved　in　cancer　development.　Moreover,　we　describe　the　crosstalk　of　RNA　modification　and　autophagy　and　review　the　recent　advances　and　potential　role　of　the　RNA　modification/autophagy　axis　in　the　development　of　multiple　cancers.　Furthermore,　the　dual　role　of　the　RNA　modification/autophagy　axis　in　cancer　drug　resistance　is　discussed.　A　comprehensive　understanding　and　extensive　exploration　of　the　molecular　crosstalk　of　RNA　modifications　with　autophagy　will　provide　important　insights　into　tumor　pathophysiology　and　provide　more　options　for　cancer　therapeutic　strategies.　©　2023　Elsevier　Inc.