Infectious　respiratory　diseases　are　known　to　have　high　levels　of　airborne　transmissibility.　However,　traditional　ventilation　methods　based　on　perfect　mixing　often　lead　to　the　diffusion　of　airborne　pathogens.　Multi-vent　module-based　adaptive　ventilation　(MAV)　is　a　ventilation　method　designed　to　meet　the　needs　of　different　indoor　scenes　and　reduce　air　mixing.　MAV　combines　multiple　groups　of　multi-vent　modules.　The　vent　spacing　of　a　single　module　is　also　an　important　factor,　but　the　influence　of　the　change　of　vent　spacing　on　the　effect　of　MAV　in　contaminant　diffusion　control　has　not　been　studied.　Computational　Fluid　Dynamics　(CFD)　is　applied　to　study　the　influence　of　air　vent　spacing　of　a　single　MAV　module　on　contaminant　diffusion　control　in　a　simple　office.　Three　different　vent　spacing　of　1.5m,　2.0m　and　2.5m　and　four　vent　layout　modes　is　selected.　The　results　show　that　when　the　vent　distance　is　2.0m,　the　MAV　system　has　the　best　control　effect　on　contaminant　diffusion.　Up　to　61.5%　of　the　contaminants　are　limited　in　the　control　area.　©　The　Authors,　published　by　EDP　Sciences.　This　is　an　open　access　article　distributed　under　the　terms　of　the　Creative　Commons　Attribution　License　4.0　(http://creativecommons.org/licenses/by/4.0/)