Lead　(Pb)　is　a　heavy　metal　commonly　found　in　industrial　exhaust　gases,　which　can　reduce　catalytic　activity　of　a　catalyst　for　the　NH3-SCR　reaction.　In　this　study,　4.0　wt%　Mn-loaded　Fe-pillared　interlayer　clay　(4Mn/Fe-PILC)　and　its　Co-modified　catalyst　(2Co-4Mn/Fe-PILC)　were　prepared,　in　the　meanwhile　the　4Mn/Fe-PILC-Pb　and　2Co-4Mn/Fe-PILC-Pb　samples　were　also　obtained　using　the　impregnation　method　with　a　Pb(CH3COO)(2)　aqueous　solution.　It　was　found　that　the　addition　of　2.0　wt%　cobalt　could　significantly　enhance　Pb　resistance　of　the　4Mn/Fe-PILC　catalyst.　The　characterization　results　revealed　that　the　doping　of　Co　to　Mn/Fe-PILC　increased　the　surface　Mn4+　species　concentration,　reducibility,　and　acid　site　amount,　thereby　improving　Pb　resistance　of　the　catalyst.　Furthermore,　the　in　situ　DRIFTS　results　demonstrated　that　Co　modification　enhanced　the　adsorption　capacity　of　NH3　or　NO,　especially　influenced　formation　of　the　NH3　intermediates　and　bridging　nitrate　species,　which　were　also　conducive　to　the　improvement　in　Pb　resistance　of　the　catalyst.