Inorganic　perovskite　quantum　dots　(PQDs)　have　been　regarded　as　attractive　materials　in　various　optoelectronic　fields　due　to　their　excellent　optical　properties,　however,　the　high　sensitivity　to　moisture,　temperature　and　ra-diation　has　put　a　limit　for　their　real　long-term　application,　and　a　more　stable　host　is　indispensable.　CsPbBr3　PQDs　with　high　stability　and　excellent　luminescence　properties　are　successfully　embedded　in　tellurite-based　glasses　by　one-step　melting　and　subsequent　heat　treatment.　Pure　cubic　structure　PQDs　with　the　radius　of　2.5-5.5　nm　are　proved　to　disperse　evenly　in　the　glass　matrix.　Thermal　and　cold　cycles,　long-term　radiation　and　humidity　exposure　have　illustrated　its　stability　and　confirmed　the　effectiveness　of　the　designed　glass　system.　The　high　photoluminescence　intensity,　wide　wavelength　tunability　of　470-508　nm　and　narrow　band-width　emission　of　31.8-36.6　nm　with　the　tunable　optical　band　gap　2.44-2.51　eV　have　demonstrated　its　excellence　as　the　opto-electronic　materials.　These　results　demonstrate　that　CsPbBr3　PQDs　embedded　in　tellurite　glass　matrix　can　overcome　existing　instability　limitation　and　provide　full　potential　of　PQDs　in　practical　photonic　and　opto-electronic　applications.