Single　crystal　Ni-based　alloys　possess　excellent　properties　such　as　high　temperature　resistance,　high　strength　and　high　toughness.　Thses　mechanical　properties　are　affected　by　secondary　orientation　and　cooling　holes　induced　during　complex　manufacturing　processes.　The　current　research　mainly　focuses　on　the　deformation　mechanism　and　mechanical　response　of　plates　with　one　hole.　While,　the　plate　with　multiple　holes　is　often　used　in　engineering.　At　present,　it　is　urgent　to　clarify　the　deformation　mechanism　of　the　plate　with　multiple　holes,　the　secondary　orientation　effect,　and　the　strain　gradient　effect　caused　by　cooling　holes.　In　this　paper,　a　nonlocal　crystal　plasticity　constitutive　model　based　on　the　dislocation　mechanism　is　used　to　numerically　simulate　the　uniaxial　tensile　deformation　behavior　of　the　Ni-based　single　crystal　plate　with　cooling　holes.　A　dislocation　flux　term　is　derived　based　on　the　relationship　between　the　plastic　slip　gradient　and　geometrically　necessary　dislocations,　enabling　this　crystal　plasticity　model　to　effectively　describe　the　strain　gradient　effect.　In　order　to　comprehensively　reveal　the　secondary　orientation　effect　of　Ni-based　alloys　with　cooling　holes,　this　paper　systematically　studies　the　uniaxial　tensile　deformation　behavior　of　sheets　with　[100]　and　[110]　orientations　(two　secondary　orientations).　The　influence　of　the　number　of　holes　on　the　plastic　behavior　of　the　plate　with　two　secondary　orientations　is　investigated.　By　analyzing　the　variation　of　the　resolved　stress　on　slip　systems,　activation　of　the　dominant　slip　systems　and　the　evolution　of　geometrically　necessary　dislocation　density　during　the　deformation　of　Ni-based　alloy　plates,　the　effects　of　plastic　slip　and　its　distribution　on　the　strength　of　Ni-based　alloy　plates　with　different　secondary　orientations　are　discussed.　The　results　show　that　the　tensile　strength　of　[110]　plate　is　lower　than　that　of　[100]　plate.　Furthermore,　the　plastic　deformation　process　of　the　five-hole　plate　is　more　complicated　than　that　of　the　one-hole　plate　and　is　easier　to　be　affected　by　secondary　orientation.　Finally,　the　location　of　the　slip　gradient　is　mainly　located　near　the　cooling　hole　and　the　plastic　slip　zone.　The　research　results　can　provide　theory　basis　for　the　design　and　service　of　Ni-based　alloys　in　engineering.　©　2023　Chinese　Journal　of　Theoretical　and　Applied　Mechanics　Press.　All　rights　reserved.